反应详情

A solution of sodium hydroxide (2.0 g) in methanol (50 ml) was added to a solution of 4-benzyloxy-3-methoxy benzoic acid methyl ester (4.64 g) in methanol (50 ml) and refluxed for 4 hrs. After removal of methanol under reduced pressure the residue was dissolved in water (150 ml) and washed with ethyl acetate (2×50 ml). The aqueous layer was acidified with 2N hydrochloric acid to pH 2. The precipitated product was collected by filtration which on drying under vacuum provided 4.17 g of 4-benzyloxy-3-methoxy benzoic acid. (Yield=74%)

1. temperaturerefluxed for 4 hrs
2. customAfter removal of methanol under reduced pressure the residue
3. dissolutionwas dissolved in water (150 ml)
4. washwashed with ethyl acetate (2×50 ml)
5. filtrationThe precipitated product was collected by filtration which
6. customon drying under vacuum