反应详情

[1-(Cyclopropylcarbamoyl-hydroxy-methyl)-butyl]-carbamic acid benzyl ester (48 g, 149.82 mmol) was dissolved in Methanol (1 L) and degassed with nitrogen for five minutes, palladium, 10 wt. % on activated carbon (2.5 g) was added, hydrogen was then added for 18 h. After 18 h the hydrogen was removed and the reaction was degassed with nitrogen and filtered the resulting filtrate was evaporated and dried under high vacuum to give a white solid 26.9 g, 144.42 mmol 97%.

1. customdegassed with nitrogen for five minutes
2. additionpalladium, 10 wt. % on activated carbon (2.5 g) was added
3. additionhydrogen was then added for 18 h
4. customAfter 18 h the hydrogen was removed
5. customthe reaction was degassed with nitrogen
6. filtrationfiltered the resulting filtrate
7. customwas evaporated
8. customdried under high vacuum