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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1999805Generated: November 2, 2026

Dimethyl Sulfate → 4-Bromo-6-chloro-2-methyl-2,3-dihydropyridazin-3-one

https://huagongshe.com/reaction/1999805

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl SulfateHCID 6497—
Reactant1445774-08-2HCID 83680573—
ReagentLithium HexamethyldisilazideHCID 2733832—
Solvent2-Methyl-2-butanolHCID 6405—
Product4-Bromo-6-chloro-2-methyl-2,3-dihydropyridazin-3-oneHCID 59216474—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-d6cfe34cf368411faa458b0e112aa366
Source note39k HTE dataset from Pfizer