Methyl 5-aminobenzofuran-2-carboxylate → N4-(3-chloro-4-methoxyphenyl)-5-fluoro-N2-[2-(methoxycarbonyl)benzofuran-5-yl]-2,4-pyrimidinediamine

HRID 199993Notes

Reaction equation

HRID 199993 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([F:18])[c:6]([NH:8][c:9]2[cH:10][c:11]([Cl:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]2)[n:7]1.[NH2:19][c:20]1[cH:21][cH:22][c:23]2[c:24]([cH:25][c:26]([C:28](=[O:29])[O:30][CH3:31])[o:27]2)[cH:32]1>>[c:2]1([NH:19][c:20]2[cH:21][cH:22][c:23]3[c:24]([cH:25][c:26]([C:28](=[O:29])[O:30][CH3:31])[o:27]3)[cH:32]2)[n:3][cH:4][c:5]([F:18])[c:6]([NH:8][c:9]2[cH:10][c:11]([Cl:17])[c:12]([O:15][CH3:16])[cH:13][cH:14]2)[n:7]1

Participants

3

Reactant 2

HCID 10845388Methyl 5-aminobenzofuran-2-carboxylateHCID 220611152-chloro-N4-(3-chloro-4-methoxyphenyl)-5-fluoro-4-pyrimidineamine

Product 1

HCID 22061081N4-(3-chloro-4-methoxyphenyl)-5-fluoro-N2-[2-(methoxycarbonyl)benzofuran-5-yl]-2,4-pyrimidinediamine

Sources & evidence

ORD record
ord-d75e4e93be09446e8edb7b67e91c3361
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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