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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2000136Generated: October 31, 2026

Benzylamine → tert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylate

https://huagongshe.com/reaction/2000136

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzylamineHCID 7504—
Reactanttert-butyl (1S,6R)-7-oxa-3-azabicyclo[4.1.0]heptane-3-carboxylateHCID 55273474—
ReagentMethanesulfonic acid, 1,1,1-trifluoro-, calcium salt (2:1)HCID 2734307—
SolventEthanolHCID 702—
Producttert-butyl (3R,4R)-4-(benzylamino)-3-hydroxypiperidine-1-carboxylateHCID 67335553—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-fe5c1998a2ee43b68f5c6b75265b3a99
Source note39k HTE dataset from Pfizer