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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2000723Generated: October 29, 2026

2-Pyridineacetic acid → 2-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamide

https://huagongshe.com/reaction/2000723

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Pyridineacetic acidHCID 85318—
Reactant5-[[(1S,3R)-3-(5-amino-1,3,4-thiadiazol-2-yl)cyclopentyl]methyl]-1,3,4-thiadiazol-2-amineHCID 118484210—
Reagent1,8-Diazabicyclo(5.4.0)undec-7-eneHCID 81184—
ReagentPropylphosphonic anhydrideHCID 111923—
SolventDimethylformamideHCID 6228—
Product2-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamideHCID 118484181—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-54465ff9118e457bac05cd83d6d9ea1e
Source note39k HTE dataset from Pfizer