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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2000989Generated: October 30, 2026

Tert-Butyl isocyanide → HCID 178440949, compound

https://huagongshe.com/reaction/2000989

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-Butyl isocyanideHCID 23577—
Reactant5-Bromo-2-tert-butylpyridineHCID 21041308—
ReactantHCID 178419779HCID 178419779—
ReagentLithium HexamethyldisilazideHCID 2733832—
Catalystpalladium(II) acetateHCID 167845—
Catalyst(R)-1-[(S)-2-(Dicyclohexylphosphino)ferrocenyl]ethyli-tert-butylphosphineHCID 117064351—
Solvent2-Methyl-2-butanolHCID 6405—
ProductHCID 178440949HCID 178440949—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-1e57cf69b6d845278ae9cfc9dc5cf87d
Source note39k HTE dataset from Pfizer