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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2001192Generated: October 29, 2026

Triethylsilicon → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2001192

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylsiliconHCID 6327258—
Reactant1,1,3-Trioxo-1,3-dihydro-2H-1lambda~6~,2-benzothiazole-2-carbaldehydeHCID 54671689—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentDiisopropylethylamineHCID 81531—
Catalyst1,3-Bis(diphenylphosphino)propaneHCID 81219—
Catalystpalladium(II) acetateHCID 167845—
SolventTetrahydrofuranHCID 8028—
Producttert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190424—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-17c74c6cef014da8b6aa93f2609e4e69
Source note39k HTE dataset from Pfizer