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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2001314Generated: October 25, 2026

Triethylsilicon → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2001314

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTriethylsiliconHCID 6327258—
Reactant1-Methyl-1,1-diphenylsilanecarboxylic acidHCID 67974019—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentDiisopropylethylamineHCID 81531—
CatalystHCID 178422001HCID 178422001—
SolventDimethylformamideHCID 6228—
Producttert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190424—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-c5d15a4c056c4031995619958df7f099
Source note39k HTE dataset from Pfizer