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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2001689Generated: October 31, 2026

Carbon Monoxide → 1-Oxoisoindoline-4-carbaldehyde

https://huagongshe.com/reaction/2001689

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbon MonoxideHCID 281—
ReactantTriethylsiliconHCID 6327258—
Reactant4-Bromoisoindolin-1-oneHCID 21907509—
ReagentDiisopropylethylamineHCID 81531—
Catalyst1,4-Bis(diphenylphosphino)butaneHCID 82124—
Catalystpalladium(II) acetateHCID 167845—
SolventTetrahydrofuranHCID 8028—
Product1-Oxoisoindoline-4-carbaldehydeHCID 72213812—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-70dc5d7edb6d44ba86c01cb5d238196f
Source note39k HTE dataset from Pfizer