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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2001779Generated: November 1, 2026

Carbon Monoxide → 1-Oxoisoindoline-4-carbaldehyde

https://huagongshe.com/reaction/2001779

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbon MonoxideHCID 281—
ReactantTriethylsiliconHCID 6327258—
Reactant4-Bromoisoindolin-1-oneHCID 21907509—
ReagentDiisopropylethylamineHCID 81531—
Catalyst[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneHCID 75537289—
SolventDimethylacetamideHCID 31374—
Product1-Oxoisoindoline-4-carbaldehydeHCID 72213812—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-638ada223ae648aeb1b35c92608cdc97
Source note39k HTE dataset from Pfizer