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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2001932Generated: October 31, 2026

Carbon Monoxide → 1-Oxoisoindoline-4-carbaldehyde

https://huagongshe.com/reaction/2001932

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbon MonoxideHCID 281—
ReactantTriethylsiliconHCID 6327258—
Reactant4-Bromoisoindolin-1-oneHCID 21907509—
ReagentDiisopropylethylamineHCID 81531—
Catalyst[1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) dichlormethaneHCID 75537289—
SolventTolueneHCID 1140—
Product1-Oxoisoindoline-4-carbaldehydeHCID 72213812—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-b0ab7da42cfe4dac94bb1061fe9a837b
Source note39k HTE dataset from Pfizer