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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2002100Generated: November 3, 2026

Carbon Monoxide → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2002100

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbon MonoxideHCID 281—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentDiisopropylethylamineHCID 81531—
Catalystpalladium(II) acetateHCID 167845—
Catalyst(Pentane-1,5-diyl)bis(di-tert-butylphosphane)HCID 611933—
SolventDimethylformamideHCID 6228—
Producttert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190424—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-5bec45e8f2cf4ba6be507520dc32d721
Source note39k HTE dataset from Pfizer