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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2002121Generated: October 29, 2026

Carbon Monoxide → tert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylate

https://huagongshe.com/reaction/2002121

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCarbon MonoxideHCID 281—
Reactanttert-butyl 6-bromo-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132189892—
ReagentDiisopropylethylamineHCID 81531—
Catalystpalladium(II) acetateHCID 167845—
CatalystHCID 178420548HCID 178420548—
SolventDimethylformamideHCID 6228—
Producttert-butyl 6-formyl-8-phenylmethoxy-3,4-dihydro-1H-isoquinoline-2-carboxylateHCID 132190424—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-ca50791a224345aca3090c3f9ce71805
Source note39k HTE dataset from Pfizer