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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2002649Generated: October 30, 2026

1-Methyl-1H-indazole-6-boronic acid → US10308615, Example 137

https://huagongshe.com/reaction/2002649

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Methyl-1H-indazole-6-boronic acidHCID 44118215—
ReactantN-(5-Bromo-2-pyrimidinyl)-5-pyrimidinemethanamineHCID 83333413—
ReagentPotassium CarbonateHCID 11430—
Catalystpalladium(II) acetateHCID 167845—
CatalystBinap, (A+-)-HCID 634876—
SolventAnisoleHCID 7519—
ProductUS10308615, Example 137HCID 134539209—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-ce0bcd43ce7a470db15763c84b07cf2f
Source note39k HTE dataset from Pfizer