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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2002665Generated: November 1, 2026

2-(Bromomethyl)pyridine hydrobromide → 2-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamide

https://huagongshe.com/reaction/2002665

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(Bromomethyl)pyridine hydrobromideHCID 2734720—
Reactant5-[[(1S,3R)-3-(5-amino-1,3,4-thiadiazol-2-yl)cyclopentyl]methyl]-1,3,4-thiadiazol-2-amineHCID 118484210—
ReagentDiisopropylethylamineHCID 81531—
Catalyst1,3-Bis(diphenylphosphino)propaneHCID 81219—
Catalystpalladium(II) acetateHCID 167845—
SolventTetrahydrofuranHCID 8028—
Product2-pyridin-2-yl-N-[5-[[(1S,3R)-3-[5-[(2-pyridin-2-ylacetyl)amino]-1,3,4-thiadiazol-2-yl]cyclopentyl]methyl]-1,3,4-thiadiazol-2-yl]acetamideHCID 118484181—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-5fb2628a7d5549e9b201b1e7337974a3
Source note39k HTE dataset from Pfizer