Potassium Cation → (4-Chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone

HRID 200281Notes

Reaction equation

HRID 200281 reaction equation
[Br:30][CH2:31][CH2:32][O:33][CH2:34][CH2:35][Br:36].[C:24](=[O:25])([O-:26])[O-:27].[K+:28].[K+:29].[NH2:1][CH2:2][c:3]1[c:4]2[n:5]([n:6][c:7]([Cl:9])[cH:8]1)[c:10]([C:14](=[O:15])[c:16]1[c:17]([F:23])[cH:18][c:19]([Cl:22])[cH:20][cH:21]1)[c:11]([CH3:13])[n:12]2.[OH2:37]>>[N:1]1([CH2:2][c:3]2[c:4]3[n:5]([n:6][c:7]([Cl:9])[cH:8]2)[c:10]([C:14](=[O:15])[c:16]2[c:17]([F:23])[cH:18][c:19]([Cl:22])[cH:20][cH:21]2)[c:11]([CH3:13])[n:12]3)[CH2:31][CH2:32][O:33][CH2:34][CH2:35]1

Participants

6

Reactant 5

HCID 813Potassium Cation2×HCID 962WaterHCID 19660Carbonate IonHCID 21521Bis(2-bromoethyl) etherHCID 86642486(8-(Aminomethyl)-6-chloro-2-methylimidazo[1,2-b]pyridazin-3-yl)(4-chloro-2-fluorophenyl)methanone

Product 1

HCID 56954584(4-Chloro-2-fluorophenyl)(6-chloro-2-methyl-8-(morpholinomethyl)imidazo[1,2-b]pyridazin-3-yl)methanone

Sources & evidence

ORD record
ord-a4606691b4d7439d99c59b0792b3116e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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