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HRID20031

反应详情

EQUATION

反应方程式

HRID 20031 的结构方程式

REACTANTS

反应物

2
结构：CC(C)[Si](c1ncc(Br)s1)(C(C)C)C(C)C
HCID59601131

未命名化合物

结构：COC(=O)[C@@H](CI)C(=O)OC(C)(C)C
HCID86614124

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)[C@H](Cc1cnc([Si](C(C)C)(C(C)C)C(C)C)s1)C(=O)OC(C)(C)C
HCID67270410

未命名化合物

PROCEDURE

实验过程

The title compound was synthesized in a manner analogous to that described Example 475, using (R)-methyl 2-(tert-butoxycarbonyl)-3-iodopropanoate and 5-bromo-2-(triisopropylsilyl)thiazole (prepared according to Stangeland, Eric L.; Sammakia, Tarek, Use of Thiazoles in the Halogen Dance Reaction: Application to the Total Synthesis of WS75624 B, Journal of Organic Chemistry (2004), 69(7), 2381-2385.). MS m/z: 443.3 (100%, M+1).

WORKUP

后处理

  1. customprepared
  2. customApplication to the Total Synthesis of WS75624 B, Journal of Organic Chemistry (2004)