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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2003107Generated: October 30, 2026

Tert-Butyl isocyanide → HCID 178440944, compound

https://huagongshe.com/reaction/2003107

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-Butyl isocyanideHCID 23577—
Reactant5-Bromo-2-tert-butylpyridineHCID 21041308—
ReactantHCID 178419779HCID 178419779—
ReagentLithium HexamethyldisilazideHCID 2733832—
Catalystpalladium(II) acetateHCID 167845—
CatalystDi-tert-butyl(2',4',6'-tris(propan-2-yl)-(1,1'-biphenyl)-2-yl)phosphaneHCID 11618717—
SolventDimethyl SulfoxideHCID 679—
ProductHCID 178440944HCID 178440944—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-f56cd549bc0a4a49844cd537bb49cb72
Source note39k HTE dataset from Pfizer