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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2003512Generated: October 31, 2026

1,1'-Biphenyl-4-yl-boronic acid → Ethyl 2-fluoro-2-(4-phenylphenyl)acetate

https://huagongshe.com/reaction/2003512

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-Biphenyl-4-yl-boronic acidHCID 151253—
ReactantAcetic acid, 2-bromo-2-fluoro-, ethyl esterHCID 2733407—
ReagentWaterHCID 962—
ReagentCesium carbonateHCID 10796—
Catalyst4,7-Dichloro-1,10-phenanthrolineHCID 219391—
Solvent1,4-DioxaneHCID 31275—
ProductEthyl 2-fluoro-2-(4-phenylphenyl)acetateHCID 21405824—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-15389bb7b3c942f5a768872c287afe57
Source note39k HTE dataset from Pfizer