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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2003519Generated: October 31, 2026

1,1'-Biphenyl-4-yl-boronic acid → Ethyl 2-fluoro-2-(4-phenylphenyl)acetate

https://huagongshe.com/reaction/2003519

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,1'-Biphenyl-4-yl-boronic acidHCID 151253—
ReactantAcetic acid, 2-bromo-2-fluoro-, ethyl esterHCID 2733407—
ReagentWaterHCID 962—
ReagentCesium carbonateHCID 10796—
Catalyst4,7-Diphenyl-1,10-phenanthrolineHCID 72812—
Solvent1,4-DioxaneHCID 31275—
ProductEthyl 2-fluoro-2-(4-phenylphenyl)acetateHCID 21405824—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-bbb97dbbd99942fa8567a0a2d69b04e9
Source note39k HTE dataset from Pfizer