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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2004416Generated: October 25, 2026

Benzene, 1-ethoxy-2-iodo- → tert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylate

https://huagongshe.com/reaction/2004416

Reaction equation

Participants

RoleNameHCIDCharge
ReactantBenzene, 1-ethoxy-2-iodo-HCID 136415—
Reactant(R)-1-Boc-3-hydroxypiperidineHCID 1514398—
ReagentPotassium t-amylateHCID 23683543—
CatalystCopper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 24350—
CatalystDinitrato(1,10-phenanthroline)copper(II)HCID 15345279—
SolventTolueneHCID 1140—
Producttert-butyl (R)-3-(2-ethoxyphenoxy)piperidine-1-carboxylateHCID 131737068—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-eef729c0c9a24b8c8f4463d26e9a51c1
Source note39k HTE dataset from Pfizer