HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 20046Generated: October 25, 2026
Hydrochloric Acid → Diethyl 2-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)malonate
https://huagongshe.com/reaction/20046
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Diethyl isopropylidenemalonate | HCID 81255 | — |
| Reactant | HCID 178490607 | HCID 178490607 | — |
| Solvent | Diethyl Ether | HCID 3283 | — |
| Product | Diethyl 2-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)malonate | HCID 67304572 | — |
Reaction Steps
Diethylisopropylidenemalonate (6.686 ml, 34.09 mmol) was dissolved in 300 ml Et2O and cooled to −78° C. 4-Methoxybenzylmagnesium chloride (150.000 ml, 37.50 mmol) was added and stirring was continued for 5 h. The temperature was warmed up to 0° C. The reaction was hydrolyzed with 0.5 M HCl and extracted 3×EtOAc. Glass col. Chromatography (10-50% EtOAc in Hex.) provided diethyl 2-(1-(4-methoxyphenyl)-2-methylpropan-2-yl)malonate. MS m/z: 323.1 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07745484B2 |
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| Source dataset | uspto-grants-2010_06 |
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| ORD ID | ord-a116fb5593f14d639fa1ae35017a6363 |
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| Source note | uspto-grants-2010_06 |
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