Diethyl(4-chlorobutyl)phosphonate → Diethyl [4-(1-methoxyethyl-3-methylxanthin-7-yl)butyl]phosphonate

HRID 2005Notes

Reaction equation

HRID 2005 reaction equation
[CH3:1][O:2][CH:3]([N:5]1[C:14](=[O:15])[C:13]2[NH:12][CH:11]=[N:10][C:9]=2[N:8]([CH3:16])[C:6]1=[O:7])[CH3:4].Cl[CH2:18][CH2:19][CH2:20][CH2:21][P:22]([O:27][CH2:28][CH3:29])(=[O:26])[O:23][CH2:24][CH3:25]>>[CH3:1][O:2][CH:3]([N:5]1[C:14](=[O:15])[C:13]2[N:12]([CH2:18][CH2:19][CH2:20][CH2:21][P:22](=[O:26])([O:27][CH2:28][CH3:29])[O:23][CH2:24][CH3:25])[CH:11]=[N:10][C:9]=2[N:8]([CH3:16])[C:6]1=[O:7])[CH3:4]

Participants

3

Reactant 2

HCID 19689195Diethyl(4-chlorobutyl)phosphonateHCID 196892351-Methoxyethyl-3-methylxanthine

Product 1

HCID 86752272Diethyl [4-(1-methoxyethyl-3-methylxanthin-7-yl)butyl]phosphonate

Procedure

The title substance was prepared from 1-methoxyethyl-3-methylxanthine and diethyl 4-chlorobutanephosphonate analogously to Example 4 and crystallized from diisopropyl ether.

Workup

  1. customcrystallized from diisopropyl ether

Sources & evidence

ORD record
ord-7fae1dd89d25493ea4ac31663986c9df
Source dataset
uspto-grants-1998_03
Patent number
US05728686

Reaction notes

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