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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2005293Generated: October 30, 2026

2-(3-(Hydroxymethyl)phenyl)acetic acid → 2-[3-(Hydroxymethyl)cyclohexyl]acetic acid

https://huagongshe.com/reaction/2005293

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-(Hydroxymethyl)phenyl)acetic acidHCID 14980952—
ReagentDiisopropylethylamineHCID 81531—
CatalystZincHCID 23994—
SolventWaterHCID 962—
SolventIsopropanolHCID 3776—
Product2-[3-(Hydroxymethyl)cyclohexyl]acetic acidHCID 105435102—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-e5c515c5ca5445b7bb546102f21e2c3f
Source note39k HTE dataset from Pfizer