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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2005317Generated: November 1, 2026

2-(3-(Hydroxymethyl)phenyl)acetic acid → 2-[3-(Hydroxymethyl)cyclohexyl]acetic acid

https://huagongshe.com/reaction/2005317

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-(3-(Hydroxymethyl)phenyl)acetic acidHCID 14980952—
ReagentDiisopropylethylamineHCID 81531—
Solvent2,2,2-TrifluoroethanolHCID 6409—
Product2-[3-(Hydroxymethyl)cyclohexyl]acetic acidHCID 105435102—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-d0152df998244e42ab3d542ddab04af2
Source note39k HTE dataset from Pfizer