HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-(1H-Imidazol-1-yl)ethanone → HCID 16747179, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-(1H-Imidazol-1-yl)ethanone | HCID 17174 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | (2R,3S)-3-amino-1-((4S)-6-bromo-2-methyl-2-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-ylamino)-4-phenylbutan-2-ol dihydrochloride | HCID 86614141 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 16747179 | HCID 16747179 | 24.7% |
Reaction Steps
To a solution of (2R,3S)-3-amino-1-((4S)-6-bromo-2-methyl-2-(trifluoromethyl)-3,4-dihydro-2H-chromen-4-ylamino)-4-phenylbutan-2-ol dihydrochloride (160 mg, 338 mmol) in DMF was added 1-(1H-imidazol-1-yl)ethanone (37.2 mg, 338 μmol) followed by DIPEA (177 μl, 1014 μmol). The reaction was stirred at RT for 30 min, then diluted with MeOH and purified on Shimadzu HPLC to afford 43.0 mg of the title compounds as a mixture. MS m/z: 515, 517.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745484B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-811784750c46412ea16a8463960b8434 |
| Source note | uspto-grants-2010_06 |