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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2006930Generated: October 25, 2026

(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acid → 4,4,4-Trifluoro-3-phenylbutanoic acid

https://huagongshe.com/reaction/2006930

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acidHCID 2054639—
ReagentMorpholineHCID 8083—
ReagentTriphenylphosphineHCID 11776—
Catalystbis((2S,5S)-1-cyclopentyl-2,5-dimethylphospholane);ironHCID 155884997—
CatalystHCID 178420233HCID 178420233—
SolventWaterHCID 962—
SolventChloroform-DHCID 71583—
Product4,4,4-Trifluoro-3-phenylbutanoic acidHCID 10376072—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-207e029177154f85bac02f41037792c6
Source note39k HTE dataset from Pfizer