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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2006971Generated: October 30, 2026

(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acid → 4,4,4-Trifluoro-3-phenylbutanoic acid

https://huagongshe.com/reaction/2006971

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acidHCID 2054639—
ReagentMorpholineHCID 8083—
ReagentTriphenylphosphineHCID 11776—
Catalyst{(1S,4R)-3-[4-(Diphenylphosphanyl)-2,5-dimethylthiophen-3-yl]-4,7,7-trimethylbicyclo[2.2.1]hept-2-en-2-yl}(diphenyl)phosphaneHCID 71310605—
CatalystHCID 178420233HCID 178420233—
SolventWaterHCID 962—
SolventChloroform-DHCID 71583—
Product4,4,4-Trifluoro-3-phenylbutanoic acidHCID 10376072—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-c39971d22bf14637b8422a75bc593541
Source note39k HTE dataset from Pfizer