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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2006992Generated: October 29, 2026

(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acid → 4,4,4-Trifluoro-3-phenylbutanoic acid

https://huagongshe.com/reaction/2006992

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(E)-4,4,4-trifluoro-3-phenylbut-2-enoic acidHCID 2054639—
ReagentMorpholineHCID 8083—
ReagentTriphenylphosphineHCID 11776—
CatalystN-[(1S,2S)-2-Aminocyclohexyl]-4-methylbenzene-1-sulfonamideHCID 16218314—
CatalystHCID 178420233HCID 178420233—
SolventWaterHCID 962—
SolventChloroform-DHCID 71583—
Product4,4,4-Trifluoro-3-phenylbutanoic acidHCID 10376072—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-c63ccd19bb984d48a1724640ddfdae57
Source note39k HTE dataset from Pfizer