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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2008681Generated: October 30, 2026

4-Methylidene-2,3-dihydroisoquinolin-1-one → 4-Methyl-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2008681

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methylidene-2,3-dihydroisoquinolin-1-oneHCID 129977777—
Catalyst[(1S,4R)-2-bicyclo[2.2.1]heptanyl]-[(1R,4S)-2-bicyclo[2.2.1]heptanyl]-[(1S)-1-[2-(2-diphenylphosphanylphenyl)cyclopentyl]ethyl]phosphane;cyclopentane;ironHCID 177697408—
CatalystRu(cod)(methallyl)2HCID 178420238—
Solvent1,2-DichloroethaneHCID 11—
SolventPropylene CarbonateHCID 7924—
Product4-Methyl-3,4-dihydroisoquinolin-1(2H)-oneHCID 14040095—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature20 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-b3efff1b2a0e4e24bff67409ec69016e
Source note39k HTE dataset from Pfizer