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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2008784Generated: October 29, 2026

4-Methylidene-2,3-dihydroisoquinolin-1-one → 4-Methyl-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2008784

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methylidene-2,3-dihydroisoquinolin-1-oneHCID 129977777—
Catalyst(1S,2S)-N-Methylsulfonyl-1,2-diphenylethanediamineHCID 11226764—
CatalystRu(cod)(methallyl)2HCID 178420238—
Solvent1,2-DichloroethaneHCID 11—
SolventPropylene CarbonateHCID 7924—
Product4-Methyl-3,4-dihydroisoquinolin-1(2H)-oneHCID 14040095—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature20 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-cb8aa2d825a4488cabb42a22fe4a0f54
Source note39k HTE dataset from Pfizer