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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2008817Generated: November 3, 2026

4-Methylidene-2,3-dihydroisoquinolin-1-one → 4-Methyl-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2008817

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-Methylidene-2,3-dihydroisoquinolin-1-oneHCID 129977777—
Catalyst2,2'-((1S,2S)-(+)-1,2-Cyclohexanediylbis((E)(nitrilomethylidyne)))bis(4-(tert-butyl)-6-(4-morpholinylmethyl)phenol), 97HCID 135502777—
CatalystHCID 178420230HCID 178420230—
Solvent1,2-DichloroethaneHCID 11—
SolventPropylene CarbonateHCID 7924—
Product4-Methyl-3,4-dihydroisoquinolin-1(2H)-oneHCID 14040095—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature20 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-dc8631bc216a4f77983e38efadd97dfc
Source note39k HTE dataset from Pfizer