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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2012110Generated: November 1, 2026

3-Cyanophenylboronic acid → 3-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrile

https://huagongshe.com/reaction/2012110

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-Cyanophenylboronic acidHCID 2734325—
Reactant6-Chloro-7-iodo-7-deazapurineHCID 14809281—
ReagentCesium fluorideHCID 25953—
CatalystTricyclohexylphosphineHCID 75806—
Catalystpalladium(II) acetateHCID 167845—
SolventMethanolHCID 887—
Product3-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-5-yl)benzonitrileHCID 86706953—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature50 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-03e44b03df1e46879199eb2cf6b2e4fa
Source note39k HTE dataset from Pfizer