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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2012241Generated: October 30, 2026

Tert-butyl 2-hydroxyacetate → HCID 178429104, compound

https://huagongshe.com/reaction/2012241

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 2-hydroxyacetateHCID 11815394—
Reactant5-Bromo-1,3-dimethyl-1H-pyrazoleHCID 21724031—
ReagentLithium HexamethyldisilazideHCID 2733832—
Catalystpalladium(II) acetateHCID 167845—
Catalyst2-(Di-tert-butylphosphanyl)-1-(2-methoxyphenyl)-1H-pyrroleHCID 46919526—
Solvent2-Methyl-2-butanolHCID 6405—
ProductHCID 178429104HCID 178429104—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-4e52c36827b740c08528f92ff74f08d3
Source note39k HTE dataset from Pfizer