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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2012290Generated: October 29, 2026

Tert-butyl 2-hydroxyacetate → HCID 178429104, compound

https://huagongshe.com/reaction/2012290

Reaction equation

Participants

RoleNameHCIDCharge
ReactantTert-butyl 2-hydroxyacetateHCID 11815394—
Reactant5-Bromo-1,3-dimethyl-1H-pyrazoleHCID 21724031—
ReagentPhenylboronic acid pinacol esterHCID 570673—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
Catalyst1,3-Bis(2,6-diisopropylphenyl)-4,5-dihydro-1H-imidazol-3-ium chlorideHCID 2734918—
CatalystDichloronickel;1,2-dimethoxyethaneHCID 15773433—
SolventTolueneHCID 1140—
ProductHCID 178429104HCID 178429104—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-864210b7c633444fb26b9058fe706d1a
Source note39k HTE dataset from Pfizer