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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2012621Generated: October 29, 2026

6-Bromoquinoline → Quinoline-6-sulfonic acid

https://huagongshe.com/reaction/2012621

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-BromoquinolineHCID 79243—
Reactant4-(Acetylamino)phenyl]imidodisulfuryl difluorideHCID 136212924—
ReagentPotassium Phosphate, TribasicHCID 62657—
Catalystpalladium(II) acetateHCID 167845—
Catalyst2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenylHCID 11155794—
SolventAcetonitrileHCID 6342—
ProductQuinoline-6-sulfonic acidHCID 316975—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-ac2c2ef085eb408d8a40f6785eb34fbf
Source note39k HTE dataset from Pfizer