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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2012950Generated: October 26, 2026

(Triethylsilyl)acetylene → 5-Chloro-3-(triethyl-silanylethynyl)-pyrazin-2-ylamine

https://huagongshe.com/reaction/2012950

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Triethylsilyl)acetyleneHCID 637947—
Reactant3-Bromo-5-chloropyrazin-2-amineHCID 10488609—
ReagentTriethylamineHCID 8471—
CatalystTriphenylphosphineHCID 11776—
Catalystpalladium(II) acetateHCID 167845—
Solvent2-MethyltetrahydrofuranHCID 7301—
Product5-Chloro-3-(triethyl-silanylethynyl)-pyrazin-2-ylamineHCID 59463522—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-2e088dc9d87942158728008ed43d0d0f
Source note39k HTE dataset from Pfizer