Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2013013Generated: October 30, 2026

(Triethylsilyl)acetylene → 5-Chloro-3-(triethyl-silanylethynyl)-pyrazin-2-ylamine

https://huagongshe.com/reaction/2013013

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(Triethylsilyl)acetyleneHCID 637947—
Reactant3-Bromo-5-chloropyrazin-2-amineHCID 10488609—
ReagentSodium BicarbonateHCID 516892—
Catalystpalladium(II) acetateHCID 167845—
CatalystDBtPFHCID 73357432—
SolventAcetonitrileHCID 6342—
Product5-Chloro-3-(triethyl-silanylethynyl)-pyrazin-2-ylamineHCID 59463522—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature25 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-0d9e305edfb24c6287d34eec19424b07
Source note39k HTE dataset from Pfizer