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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2013348Generated: October 29, 2026

6-Chloroquinoline → 6-(6-Methoxypyridin-3-yl)quinoline

https://huagongshe.com/reaction/2013348

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-ChloroquinolineHCID 69163—
ReactantHCID 178492810HCID 178492810—
ReagentCesium carbonateHCID 10796—
ReagentTetrabutylammonium BromideHCID 74236—
CatalystDi-tert-butylmethylphosphineHCID 4190634—
CatalystN-(4-decylphenyl)-1,1,4-trioxo-2,3-dihydrothiochromene-3-carboxamideHCID 14255919—
SolventPropionitrileHCID 7854—
Product6-(6-Methoxypyridin-3-yl)quinolineHCID 122392050—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-cda25cba4680401e83c8dc556117c563
Source note39k HTE dataset from Pfizer