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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2013387Generated: October 29, 2026

6-Chloroquinoline → 6-(6-Methoxypyridin-3-yl)quinoline

https://huagongshe.com/reaction/2013387

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-ChloroquinolineHCID 69163—
ReactantHCID 178492810HCID 178492810—
ReagentCesium carbonateHCID 10796—
Catalystpalladium(II) acetateHCID 167845—
CatalystDi-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-(1,1'-biphenyl)-2-yl)phosphineHCID 44233348—
Solvent1,4-DioxaneHCID 31275—
Product6-(6-Methoxypyridin-3-yl)quinolineHCID 122392050—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-ef3cfa6a6c8a4ba0bd9b70ba9fde7801
Source note39k HTE dataset from Pfizer