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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2013457Generated: October 30, 2026

6-Bromoquinoline → 6-(6-Methoxypyridin-3-yl)quinoline

https://huagongshe.com/reaction/2013457

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-BromoquinolineHCID 79243—
ReactantHCID 178492810HCID 178492810—
ReagentPotassium CarbonateHCID 11430—
ReagentTetrabutylammonium BromideHCID 74236—
Catalystpalladium(II) acetateHCID 167845—
CatalystDi-tert-butyl(2',4',6'-triisopropyl-3,6-dimethoxy-(1,1'-biphenyl)-2-yl)phosphineHCID 44233348—
Solvent2-Methyl-2-butanolHCID 6405—
Product6-(6-Methoxypyridin-3-yl)quinolineHCID 122392050—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-20ee2ca02e60477ea8318a1ec1801fec
Source note39k HTE dataset from Pfizer