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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2013521Generated: October 30, 2026

6-Chloroquinoline → 6-(6-Methoxypyridin-3-yl)quinoline

https://huagongshe.com/reaction/2013521

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-ChloroquinolineHCID 69163—
ReactantHCID 178492810HCID 178492810—
ReagentCesium carbonateHCID 10796—
ReagentTetrabutylammonium BromideHCID 74236—
Catalystpalladium(II) acetateHCID 167845—
CatalystN,N-DIETHYLDINAPHTHO[2,1-D:1',2'-F][1,3,2]DIOXAPHOSPHEPIN-4-AMINEHCID 11058169—
Solvent2-Methyl-2-butanolHCID 6405—
Product6-(6-Methoxypyridin-3-yl)quinolineHCID 122392050—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature100 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-662239a89d9f43fc8ae7b03c3dca80f5
Source note39k HTE dataset from Pfizer