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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2013720Generated: October 30, 2026

1-Methylimidazole → HCID 178480578, compound

https://huagongshe.com/reaction/2013720

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-MethylimidazoleHCID 1390—
ReactantTert-butyl 4-{[(2-amino-5-bromopyridin-3-yl)oxy]methyl}piperidine-1-carboxylateHCID 121409255—
ReagentPotassium phosphate, tribasic, monohydrateHCID 22031701—
CatalystTricyclohexylphosphineHCID 75806—
Catalystpalladium(II) acetateHCID 167845—
SolventDimethylacetamideHCID 31374—
ProductHCID 178480578HCID 178480578—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature110 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-fdc49172ef6a4bd3b11693b73b603902
Source note39k HTE dataset from Pfizer