Carbonate Ion → 6-[2-(3-Hydroxy-pyrrolidine-1-carbonyl)-thieno[3,2-b]pyridin-7-yloxy]-2-methyl-1H-indole-3-carboxylic acid methylamide

HRID 201492Notes

Reaction equation

HRID 201492 reaction equation
[C:34](=[O:35])([O-:36])[O-:37].[CH3:19][NH:20][C:21](=[O:22])[c:23]1[c:24]([CH3:33])[nH:25][c:26]2[cH:27][c:28]([OH:32])[cH:29][cH:30][c:31]12.[Cl:1][c:2]1[c:3]2[c:4]([n:5][cH:6][cH:7]1)[cH:8][c:9]([C:11](=[O:12])[N:13]1[CH2:14][CH:15]([OH:18])[CH2:16][CH2:17]1)[s:10]2.[Cs+:38].[Cs+:39]>>[c:2]1([O:32][c:28]2[cH:27][c:26]3[nH:25][c:24]([CH3:33])[c:23]([C:21]([NH:20][CH3:19])=[O:22])[c:31]3[cH:30][cH:29]2)[c:3]2[c:4]([n:5][cH:6][cH:7]1)[cH:8][c:9]([C:11](=[O:12])[N:13]1[CH2:14][CH:15]([OH:18])[CH2:16][CH2:17]1)[s:10]2

Participants

5

Reactant 4

HCID 19660Carbonate IonHCID 104967Cesium cation2×HCID 207678626-Hydroxy-2-methyl-1H-indol-3-carboxylic acid methylamideHCID 22143479(7-Chloro-thieno[3,2-b]pyridin-2-yl)-(3-hydroxy-pyrrolidin-1-yl)-methanone

Product 1

HCID 104789306-[2-(3-Hydroxy-pyrrolidine-1-carbonyl)-thieno[3,2-b]pyridin-7-yloxy]-2-methyl-1H-indole-3-carboxylic acid methylamide

Sources & evidence

ORD record
ord-729b970414f548168758f00029f9501f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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