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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2015413Generated: October 29, 2026

3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopenten-1-one → N-[6-(3-oxocyclopenten-1-yl)pyridazin-3-yl]-2-pyridin-2-ylacetamide

https://huagongshe.com/reaction/2015413

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyclopenten-1-oneHCID 66822876—
ReactantN-(6-bromopyridazin-3-yl)-2-pyridin-2-ylacetamideHCID 118484205—
ReagentPotassium Phosphate, TribasicHCID 62657—
CatalystDichloro-(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)palladium(II)HCID 60153068—
SolventTetrahydrofuranHCID 8028—
ProductN-[6-(3-oxocyclopenten-1-yl)pyridazin-3-yl]-2-pyridin-2-ylacetamideHCID 118484176—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature80 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-141c009899324aec9c4ffb7d1f722981
Source note39k HTE dataset from Pfizer