Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2015695Generated: October 30, 2026

Water → tert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylate

https://huagongshe.com/reaction/2015695

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantPyrazolo(1,5-a)pyrimidineHCID 11636795—
Reactant(R)-tert-butyl 3-(4-bromo-N-(3-chloropyridin-2-yl)benzamido)piperidine-1-carboxylateHCID 117652956—
ReagentPotassium AcetateHCID 517044—
CatalystHCID 178491333HCID 178491333—
Solvent2-Methyl-2-butanolHCID 6405—
Producttert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylateHCID 118898588—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-38195f267e854195bb2344cf207242f2
Source note39k HTE dataset from Pfizer