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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2015706Generated: October 29, 2026

Water → tert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylate

https://huagongshe.com/reaction/2015706

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantPyrazolo(1,5-a)pyrimidineHCID 11636795—
Reactant(R)-tert-butyl 3-(4-bromo-N-(3-chloropyridin-2-yl)benzamido)piperidine-1-carboxylateHCID 117652956—
ReagentPotassium AcetateHCID 517044—
Catalyst(2',4'-Diisopropyl-3-methoxy-6-methyl-6'-propyl-2-biphenylyl)[bis(2-methyl-2-propanyl)]phosphineHCID 56641709—
Solvent2-Methyl-2-butanolHCID 6405—
Producttert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylateHCID 118898588—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-edbf81bb156747fea4079788b3bf8486
Source note39k HTE dataset from Pfizer