Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2015786Generated: October 30, 2026

Water → tert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylate

https://huagongshe.com/reaction/2015786

Reaction equation

Participants

RoleNameHCIDCharge
ReactantWaterHCID 962—
ReactantPyrazolo(1,5-a)pyrimidineHCID 11636795—
Reactant(R)-tert-butyl 3-(4-bromo-N-(3-chloropyridin-2-yl)benzamido)piperidine-1-carboxylateHCID 117652956—
ReagentPotassium AcetateHCID 517044—
Catalyst1,3-Dicyclohexyl-1H-imidazol-3-ium tetrafluoroborateHCID 16218169—
Solvent2-Methyl-2-butanolHCID 6405—
Producttert-butyl (3R)-3-[(3-chloro-2-pyridinyl)-(4-pyrazolo[1,5-a]pyrimidin-3-ylbenzoyl)amino]piperidine-1-carboxylateHCID 118898588—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-5ecf878061c3481892970b26387ed05d
Source note39k HTE dataset from Pfizer