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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2015811Generated: October 26, 2026

1,4-Dimethyl-1H-1,2,3-triazole → {[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-one

https://huagongshe.com/reaction/2015811

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-Dimethyl-1H-1,2,3-triazoleHCID 15257142—
Reactant2-((2-(benzyloxy)-4,6-dimethylpyridin-3-yl)methyl)-7-bromo-5,8-dichloro-3,4-dihydroisoquinolin-1(2H)-oneHCID 86723728—
ReagentCesium pivalateHCID 583616—
CatalystDichloro-(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)palladium(II)HCID 60153068—
SolventDimethylacetamideHCID 31374—
Product{[2-(benzyloxy)-4,6-dimethylpyridin-3-yl]methyl}-5,8-dichloro-7-(1,4-dimethyl-1H-1,2,3-triazol-5-yl)-3,4-dihydroisoquinolin-1(2H)-oneHCID 86723731—
Internal standard9-PhenylanthraceneHCID 11766—

Reaction Conditions

Temperature90 °C

Provenance & Evidence

DOI10.1038/s41557
Source dataset39k HTE dataset from Pfizer
ORD IDord-ce451b501c25471387ab3624e5e1dfa9
Source note39k HTE dataset from Pfizer